Cationic lipophosphoramidates and lipophosphoguanidines are very efficient for in vivo DNA delivery |
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Authors: | Picquet Erwann Le Ny Karine Delépine Pascal Montier Tristan Yaouanc Jean-Jacques Cartier Dominique des Abbayes Hervé Férec Claude Clément Jean-Claude |
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Affiliation: | UMR CNRS 6521, UFR Sciences et Techniques, Université de Bretagne Occidentale, 6, Av. Le Gorgeu, C.S. 93837, F-29238 Brest Cedex 3, France. |
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Abstract: | Two new families of cationic lipids were designed and synthesized for gene delivery, namely "lipophosphoramidates" and "lipophosphoguanidines", whose efficiency was noteworthy. The most efficient have an arsonium cation as the polar head, and the unsaturated lipidic tails (e.g. oleyl) gave the better in vivo results (mice lungs). |
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