The dual effect of enflurane on gill withdrawal reflex ofAplysia |
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Authors: | Hisao Komatsu Ken Lukowiak Kenji Ogli |
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Affiliation: | (1) Neuroscience Research Group, Faculty of Medicine, University of Calgary, T2N 4N1 Calgary, Alberta, Canada;(2) Department of Anesthesiology and Emergency Medicine, Kagawa Medical School, 1750, Ikenobe, Miki-cho, 761-07 Kagawa, Japan |
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Abstract: | Superfusion of clinical concentrations of enflurane (0.5% or 1.0%), an inhalation anaesthetic, over the abdominal ganglion ofAplysia significantly affected the amplitude of the gill withdrawal reflex evoked by tactile stimulation of the siphon. Enflurane superfusion (0.5%) suppressed the gill withdrawal reflex amplitude (to 46.1% of control; P<0.001 vs control) in eight of ten experiments. In the remaining two experiments, enflurane superfusion of the abdominal ganglion significantly facilitated the gill withdrawal reflex amplitude (174.5% of control;P<0.01). In addition, enflurane superfusion significantly reduced the number of action potentials evoked in central gill motor neurons by the siphon stimulation (to 47.1% of control;P<0.01) in six out of nine experiments. In one of the remaining three experiments, enflurane increased the number of action potentials evoked by the stimulus (to 200.0% of control). In two of the three, enflurane did not alter the numbet of action potentials. Behavioural responses were ‘uncoupled’ from the neuronal responses as a result of enflurane superfusion. |
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Keywords: | abdominal ganglion Aplysia enflurane gill withdrawal reflex |
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