The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans. |
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| Authors: | C San Jos , R A Monge, R P rez-Dí az, J Pla, C Nombela |
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| Affiliation: | C San José, R A Monge, R Pérez-Díaz, J Pla, and C Nombela |
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| Abstract: | The Candida albicans HOG1 gene (HOG1CA) was cloned by functional complementation of the osmosensitive phenotype associated with Saccharomyces cerevisiae hog1 delta mutants. HOG1CA codes for a 377-amino-acid protein, 78% identical to S. cerevisiae Hog1p. A C. albicans hog1 null mutant was found to be sensitive to osmotic stress and failed to accumulate glycerol on high-osmolarity media. |
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