Immobilization of human thrombomodulin on glass beads and its anticoagulant activity. |
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| Authors: | M Akashi I Maruyama N Fukudome E Yashima |
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| Institution: | Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University, Japan. |
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| Abstract: | Human thrombomodulin (TM) was for the first time immobilized on glass beads by the reaction between the carboxyl group of TM and the amino group of glass beads using water-soluble carbodiimide. Immobilized human TM exhibited both anticoagulant activity and inhibition of platelet aggregation of human blood. |
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