Purine salvage by Acanthamoeba castellanii |
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| Authors: | H F Hassan G H Coombs |
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| Affiliation: | 1. Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan;2. Department of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan;3. Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan |
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| Abstract: | Trophozoites of Acanthamoeba castellanii were found to incorporate a range of purine bases and nucleosides into parasite nucleic acids. Results from competition studies suggest that A. castellanii is capable of interconverting purine nucleotides. The amoebae contain deaminase, phosphorylase, kinase, phosphoribosyltransferase and 5'-nucleotidase activities towards a number of purine compounds. The results of both the incorporation studies and the enzyme analyses suggest that hypoxanthine is of central importance in the parasite's purine metabolism. |
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