Postnatal development of the actual and total activity of the branched-chain 2-oxo acid dehydrogenase complex in rat tissues |
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| Authors: | J H Veerkamp A J Wagenmakers |
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| Affiliation: | 1. MRC Mitochondrial Biology Unit, University of Cambridge, The Keith Peters Building, Cambridge, CB2 0XY, UK;2. Department of Medicine, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK;1. Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA;2. Department of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA;3. Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA |
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| Abstract: | Actual and total activities of the branched-chain 2-oxo acid dehydrogenase complex were determined in homogenates of quadriceps muscle, heart, liver, kidney and brain from rats of 0-70 days age. All rat tissues except quadriceps muscle showed a marked increase of total activity between 0 and 21 days, heart and kidney also after weaning. The actual activity rose after birth in liver, kidney and brain and after weaning in liver, kidney and heart. The activity state was always about 100% in liver and varied between 40-60% in kidney and brain, 10-23% in heart and 6-12% in quadriceps muscle. The actual activities measured indicate, that the degradation of branched-chain 2-oxo acids mainly takes place in the liver of the newborn, suckling and young-adult rat. |
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