一氧化氮参与低氧脑血管张力调节

本工作是初生小牛基底动脉血管条上，用一氧化氮合成酶抑制剂－Ｌ－硝基精氨酸研究ＮＯ及内皮细胞在低氧脑血管扩张机制中的作用。实验结果表明，Ｌ－ＮＮＡ可减弱低氧扩血管作用，但减少的值要小于常氧下相同浓度Ｌ－ＮＮＡ所引起的作用。

PARTICIPATE OF NITRIC OXIDE PARTICIPATE IN HYPOXIC REGULATION OF CEREBROVASCULAR TENSION

Making use of nitric oxide synthesase (NOS) inhibitor Nw - nitric - oxide - L-arginine (L-NNA), the effect of NO and the pressence of endothelial cell on hypoxia-induced vascular dilatation was studied with new-born calve basilar artery. The experimental resultsshow that L-NNA can attenuate the hypoxia-induced vascular dilatation, but the magnitude of attenuation is smaller than that of constriction caused by L-NNA on normoxic calve basilar artery. Under hypoxia, the vascular dilatation of endothelial cell denuded artery is smaller than that of endothelial cell intact artery; the difference between them is approximate by the same as the change caused by L-NNA on endothelial call intact artery. After destroying the endothelial cell, L-NNA has no obvious effect on the vascular tension. These results suggest that NO and endothelial cell are involved in hypoxia-induced vascular dilaxation.