CXCR5 identifies a subset of Vgamma9Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production |
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| Authors: | Caccamo Nadia Battistini Luca Bonneville Marc Poccia Fabrizio Fournié Jean Jacques Meraviglia Serena Borsellino Giovanna Kroczek Richard A La Mendola Carmela Scotet Emmanuel Dieli Francesco Salerno Alfredo |
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| Institution: | Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Palermo, Italy. |
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| Abstract: | Vgamma9Vdelta2 T lymphocytes recognize nonpeptidic Ags and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in Ab-mediated immune responses. We show here that expression of CXCR5 identifies a unique subset of Vgamma9Vdelta2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production. These properties portray CXCR5+ Vgamma9Vdelta2 T cells as a distinct memory T cell subset with B cell helper function. |
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