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Models of the inositol trisphosphate receptor |
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| Authors: | Sneyd J Falcke M |
| Institution: | aDepartment of Mathematics, University of Auckland, Auckland, New Zealand bHahn Meitner Institute, SF5, Glienicker Str. 100, 14109 Berlin, Germany |
| Abstract: | The inositol (1,4,5)-trisphosphate receptor (IPR) plays a crucial role in calcium dynamics in a wide range of cell types, and is often a central feature in quantitative models of calcium oscillations and waves. We review deterministic and stochastic mathematical models of the IPR, from the earliest ones of the 1970s and 1980s, to the most recent. The effects of IPR stochasticity on Ca2+ dynamics are briefly discussed. |
| Keywords: | Inositol trisphosphate receptor Calcium oscillations Mathematical model Calcium waves Stochastic models Adaptation Monod–Wyman–Changeux models Review |
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