Renal function and plasma arginine vasotocin during an acute salt load in feral chickens |
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Authors: | Juliet R Roberts |
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Institution: | (1) Department of Physiology, University of New England, 2351 Armidale, N.S.W., Australia |
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Abstract: | Summary Renal clearance experiments were conducted on feral chickens descended from birds collected from a coral island off the coast of Queensland, Australia. Following a control period when 0.13 M NaCl was used as a vehicle for the renal function markers, a salt load was imposed by infusion of 1 M NaCl. The hypertonic NaCl infusion resulted in increases in glomerular filtration rate (GFR), effective renal blood flow (ERBF), and urine flow rate (V), whereas filtration fraction decreased. Haematocrit was reduced and plasma osmolality, sodium, chloride and potassium concentrations increased. Plasma arginine vasotocin (PAVT) levels increased from 31.4±2.3 pg·ml-1 during the control infusion to 56.0±1.7 pg·ml-1 following a salt load of 12 mmol Nacl·kg-1 The sensitivity of release of AVT was 0.69±0.11 pg·ml-1 per mosmol·kg-1. The concentrations of Na and Cl in urine increased, whereas urine osmolality and potassium concentration decreased. The expansion of the extracellular fluid volume induced by the salt loading would tend to suppress the release of AVT, whereas the osmotic stimulus would provide a stimulus for the release of AVT. In this study, GFR, ERBF and ERPF increased at the same time as PAVT increased.Abbreviations AVP
arginine vasopressin
- AVT
arginine vasotocin
- ERBF
effective renal blood flow
- ERPF
effective renal plasma flow
- GFR
glomerular filtration rate
- Pavt
plasma arginine vasotocin concentration
- PAH
paraaminohippuric acid
- SEM
standard error of mean
- SNGER
single nephron glomerular filtration rate
- U/P
urine to plasma ratio
- V
urine flow rate |
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Keywords: | Renal function Salt loading Arginine vasotocin Feral chicken Renal blood flow |
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