Vdelta1+ T cells are crucial for repertoire formation of gammadelta T cells in the lung |
| |
Authors: | Li Shigen Kishihara Kenji Akashi Nobuko Hara Hiromitsu Yoshikai Yasunobu Maekawa Yoichi Yasutomo Koji |
| |
Affiliation: | a Department of Immunology and Parasitology, Institute of Health Biosciences, The University of Tokushima School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan b Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan c Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan |
| |
Abstract: | The pulmonary resident T lymphocytes (RPLs) expressing a nearly invariant T cell receptor γδ heterodimer (γδTCR) migrate from fetal thymus to the lung epithlium, followed by RPL subsets expressing diverse sets of γδTCRs after birth. However, it remains unclear whether the fetal type Vγ6/Vδ1+ RPLs are essential for γδ T cell repertoire formation in the lung epithelium. In this study, we found a marked decrease in the number of γδRPLs at 4 weeks of age in Vδ1−/− mice and they predominantly expressed Vγ6 and Vδ4 genes. The skewed diversity towards the Vδ4-(Dδ1)-Dδ2-Jδ2 junctional region was observed only in γδ RPLs from 4-week-old Vδ1−/− mice, compared with those from 8-week-old Vδ1−/− mice and the both ages of wild-type mice. These results suggest that the invariant Vδ1+ T cells are crucial not only for optimal γδ T cell expansion but also for affecting the migration or microenvironment for other γδ T cells in the lung epithelium. |
| |
Keywords: | RPL, resident pulmonary T lymphocyte TCR, T cell receptor DETC, dendritic epidermal T lymphocyte |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|