Combinatorial chemistry,automation and molecular diversity: new trends in the pharmaceutical industry |
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| Institution: | 1. Department of Anesthesiology, Yixing People''s Hospital, Yixing, China;2. Department of Urology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China;3. Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China;4. Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China;5. Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China;6. Department of General Surgery, Yixing Tumor Hospital, Yixing, China;7. Department of Urology, Jiangsu Province Hospital of TCM, Nanjing, China;8. Department of Integrated Traditional Chinese and Western Medicine, Tumor Research Lab, Nanjing, China |
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| Abstract: | Combinatorial chemistry has emerged as a set of novel strategies for the synthesis of large sets of compounds (combinatorial libraries) for biological evaluation. Within a few years combinatorial chemistry has undergone a series of changes in trends, which are closely related to two important factors in libraries: numbers and quality. While the number of compounds in a library may be easily expressed, it is a lot more difficult to indicate the degree of quality of a library. This degree of quality can be split into two aspects : purity and diversity. The changing trends in combinatorial chemistry with respect to the strategies, the technologies, the libraries themselves (numbers and purity aspects) and the molecular diversity are outlined in this paper. |
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