(1) Department of Cell and Developmental Biology and Laboratories for Reproductive Biology, The University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC, 27599, USA
Abstract:
Background
Spermatogenesis is an androgen-dependent process, yet the molecular mechanisms of androgens' actions in testis are poorly understood. Transgenic mice overexpressing rat androgen-binding protein (ABP) in their testes have reduced levels of intratesticular androgens and, as a result, show a progressive impairment of spermatogenesis. We used this model to characterize changes in global gene expression in testis in response to reduced bioavailability of androgens.
