Prenatal identification of a deleted Y chromosome by cytogenetics and a Y-specific repetitive DNA probe |
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| Authors: | C. Disteche D. Luthy D. B. Haslam D. Hoar |
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| Affiliation: | (1) Department of Pathology, University of Washington, 98195 Seattle, WA, USA;(2) Department of Obstetrics and Gynecology, Swedish Hospital Medical Center, 98104 Seattle, WA, USA;(3) Molecular Diagnosis Laboratory, Division of Medical Genetics, Alberta Children's Hospital Research Center, ALB T21 5C7 Calgary, Canada |
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| Abstract: | Summary A very small sex chromosome was identified prenatally as a Y chromosome by using molecular hybridization in conjunction with conventional cytogenetics techniques. The combination of R-banding, Q-banding, distamycin-DAPI staining suggested that the chromosome might be a de novo deletion of the Y chromosome as the father's Y chromosome was normal. Restriction enzyme analysis of amniotic fluid cell DNA using a Y chromosome repetitive probe confirmed the origin of this chromosome. |
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