Perspectives of biotechnological production of <Emphasis Type="SmallCaps">l</Emphasis>-ribose and its purification |
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Authors: | Chao Hu Liangzhi Li Yayue Zheng Lilian Rui Cuiying Hu |
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Institution: | (1) School of Chemistry and Bioengineering, Suzhou University of Science and Technology, Suzhou, 215011, People’s Republic of China; |
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Abstract: | l-Ribose is a non-natural and expensive sugar that can be used as an important intermediate for the synthesis of l-nucleoside analogues, which are used as antiviral drugs. In contrast to chemical production, biotechnological methods can
produce l-ribose from biomass under environmentally friendly conditions. In this mini-review, various strategies for synthesizing l-ribose by applying microorganisms and their enzymes are discussed, including microbial biotransformation and biocatalysis
by engineering bacteria. Furthermore, subsequent isolation-and-purification techniques, as an integral step in the whole process,
are accordingly described, containing the especial introduction of a promising strategy of l-ribose separation. Particularly, further researches and outlook for the improvement of l-ribose preparation was solely stressed. Compared with each method, this mini-review provides a panorama of respective advantages
and disadvantages existing in them. |
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