Dynamin-1-like protein (Dnm1L) interaction with kinesin light chain 1 (KLC1) through the tetratricopeptide repeat (TPR) domains |
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| Authors: | Won Hee Jang Young Joo Jeong Sun Hee Choi Sang-Jin Kim Sang-Hwa Urm |
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| Affiliation: | 1. Department of Biochemistry and u-HARC, Inje University College of Medicine, Busan, Korea;2. Department of Neurology, Inje University College of Medicine, Busan, Korea;3. Department of Preventive Medicine, Inje University College of Medicine, Busan, Korea |
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| Abstract: | Kinesin light chain 1 (KLC1) mediates binding of KIF5 motor to specific cargo. Using the yeast two-hybrid screening, we found that mitochondrial fission protein dynamin-1-like protein (Dnm1L) interacted with KLC1, but not KIF5. Dnm1L and KLC1 were co-localized in cultured cells. These results suggest that KLC1 may play a potential role in post-fission mitochondrial transport. |
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| Keywords: | kinesin 1 KLC1 TPR domain Dnm1L |
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