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Effects of Korean Red Ginseng extract on hepatic lipid accumulation in HepG2 cells |
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| Authors: | Mak-Soon Lee Chong-Tai Kim In-Hwan Kim |
| Affiliation: | 1. Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Korea;2. Convergence Technology Research Group, Korea Food Research Institute, Seongnam, Republic of Korea;3. Department of Food and Nutrition, Korea University, Seoul, Republic of Korea |
| Abstract: | In this study, we investigated the effects of Korean red ginseng water extract (KRGE) on hepatic lipid accumulation in HepG2 cells. KRGE decreased hepatic triglyceride and cholesterol levels. Further, KRGE suppressed expression of fatty acid synthase (FAS) and 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase. These results suggest that KRGE may reduce hepatic lipid accumulation by inhibition of FAS and HMG-CoA reductase expression in HepG2 cells. |
| Keywords: | Korean red ginseng water extract (KRGE) hepatic lipid accumulation fatty acid synthase (FAS) 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase HepG2 cells |