Protective effects of oral administration of yeast thioredoxin against gastric mucosal injury |
| |
| Authors: | Yukiko Taketani Kimihiro Kinugasa Rie Kitajima Shin Nishiumi Hitoshi Ashida Hajime Nakamura |
| |
| Affiliation: | 1. Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd., Nagahama, Japantaketani.yukiko@nisshin.com;3. Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd., Nagahama, Japan;4. Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe, Japan;5. Department of Preventive Medicine, The Tazuke Kofukai Medical Research Institute Kitano Hospital, Osaka, Japan |
| |
| Abstract: | Thioredoxin (TRX) is a redox regulating protein which has protective effects against oxidative stress-induced damage to cells and tissues. In this study, we investigated the effects of orally administered TRX derived from edible yeast, Saccharomyces cerevisiae, on gastric mucosa. First, we examined the digestibility of orally administered yeast TRX in mice, and detected yeast TRX in the stomach for 4?h after administration. Next, we investigated the mitigation of gastric mucosal injury after the oral administration of yeast TRX in water-immersion restraint stress and HCl/ethanol-induced gastric ulcer models. Furthermore, we conducted DNA microarray analysis, using the HCl/ethanol-induced model, which revealed that several groups of genes related to tissue repair were upregulated in ulcer regions in the stomachs of rats administered with yeast TRX. These results demonstrated the viability of the use of oral administrations of yeast TRX to protect the gastric mucosa. |
| |
| Keywords: | thioredoxin yeast oral administration gastric mucosal injury |
|
|
