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Randomized controlled trial of a water-soluble formulation of lutein in humans |
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| Authors: | Junya Kobayashi Etsuko Tominaga Makoto Ozeki Tsutomu Okubo Kiyotaka Nakagawa Teruo Miyazawa |
| Affiliation: | 1. Division of Nutrition, Taiyo Kagaku Co., Ltd., Yokkaichi, Japanjukobayashi@taiyokagaku.co.jp;3. Division of Nutrition, Taiyo Kagaku Co., Ltd., Yokkaichi, Japan;4. Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan;5. Food and Biotechnology Innovation Project, New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai, Japan;6. Food and Health Science Research Unit, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan |
| Abstract: | ABSTRACTLutein is poorly absorbed owing to their high hydrophobicity and crystallinity. This double-blind crossover trial involved eight healthy males who were administrated capsules containing either a lutein water-soluble formulation or a lutein oil suspension for 8 days. In the formulation group, plasma and erythrocytes lutein concentrations and baseline-corrected AUC were two-fold higher than those in the oil suspension group. |
| Keywords: | Lutein formulation bioavailability |