Adaptation of Hydrogenobacter thermophilus toward oxidative stress triggered by high expression of alkyl hydroperoxide reductase |
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| Authors: | Yuya Sato Hiroyuki Arai Yasuo Igarashi |
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| Affiliation: | 1. Department of Biotechnology, Graduate School of Agricultural and Life Science, The University of Tokyo, Tokyo, Japan;2. Research Institute for Environmental Management Technology, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan |
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| Abstract: | Ferriperoxin is a novel peroxidase essential for aerobiosis of Hydrogenobacter thermophilus. Although the ferriperoxin-deficient mutant (Δfpx) was unable to grow aerobically, a suppressor mutant capable of aerobic growth was obtained after long aerobic cultivation. The alkyl hydroperoxide reductase gene was significantly upregulated in the suppressor mutant, indicating that the enzyme counteracts oxidative stress in the absence of ferriperoxin. |
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| Keywords: | ferriperoxin rubrerythrin ahpC oxidative stress defense |
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