Identification of a quorum sensing pheromone posttranslationally farnesylated at the internal tryptophan residue from Bacillus subtilis subsp. natto |
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Authors: | Shunsuke Hayashi Syohei Usami Yuta Nakamura Koki Ozaki |
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Affiliation: | Graduate School of Bioscience and Biotechnology, Chubu University, Kasugai, Japan |
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Abstract: | Bacillus subtilis subsp. natto produces poly-γ-glutamic acid under the control of quorum sensing. We identified ComXnatto pheromone as the quorum-sensing pheromone with an amino acid sequence of Lys-Trp-Pro-Pro-Ile-Glu and the tryptophan residue posttranslationally modified by a farnesyl group. ComXnatto pheromone is unique in the sense that the 5th tryptophan residue from the C-terminal is farnesylated. |
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Keywords: | Bacillus subtilis isoprenylation posttranslational modification quorum sensing tryptophan |
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