Synthesis and degranulation-inhibiting activities of the proposed apteniols B,C, and G |
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| Authors: | Toshiro Noshita Akihiro Tai Hikaru Nishikawa Kaoru Ikeda Hidekazu Ouchi Yoshitomo Hamada |
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| Affiliation: | 1. Faculty of Life and Environmental Sciences, Department of Life Sciences, Prefectural University of Hiroshima, Hiroshima, Japan;2. Program in Biological System Sciences, Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima, Hiroshima Japannoshita@pu-hiroshima.ac.jp;4. Program in Biological System Sciences, Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima, Hiroshima Japan;5. Program in Biological System Sciences, Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima, Hiroshima Japan;6. Faculty of Pharmaceutical Education, Department of Pharmacy, Kinki University, Osaka, Japan;7. Graduate School of Engineering, Osaka Electro-Communication University, Osaka Japan |
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| Abstract: | The synthesis of compounds with the structures proposed for the oxyneolignan apteniols B, C, and G is described. The diphenyl ether skeletons of the proposed apteniols were formed via Ullmann ether synthesis. In particular, the spectral data for the synthesized apteniols B, C, and G did not agree with those previously reported for the isolated compounds. Furthermore, the synthesized proposed apteniol B did not show degranulation-inhibiting activity, while the prepared proposed apteniols C and G exhibited activities considerably weaker than that of the methyl ester of proposed apteniol A. |
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| Keywords: | Aptenia cordifolia oxyneolignan Ullmann ether synthesis apteniol, degranulation-inhibiting activity |
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