Antiallergic activity of rosmarinic acid esters is modulated by hydrophobicity,and bulkiness of alkyl side chain |
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| Authors: | Fengxian Zhu Zhongming Xu Lina Yonekura Ronghua Yang |
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| Affiliation: | 1. The United Graduate School of Agricultural Sciences, Ehime University, Matsuyama, Japan;2. College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, China;3. The Graduate School of Agriculture, Kagawa University, Miki-cho, Kagawa, Japan |
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| Abstract: | Methyl, propyl and hexyl esters of rosmarinic, caffeic and p-coumaric acids were tested for antiallergic activity, and rosmarinic acid propyl ester exhibited the greatest β-hexosaminidase release suppression (IC50, 23.7 μM). Quadratic correlations between pIC50 and cLogP (r2 = 0.94, 0.98, and 1.00, respectively) were observed in each acid ester series. The antiallergic activity is modulated by hydrophobicity, and alkyl chain bulkiness. |
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| Keywords: | rosmarinic acid esterification antiallergic activity hydrophobicity bulkiness |
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