Urine 3-hydroxykynurenine is higher during the postovulatory phase than in the preovulatory phase indicating a higher vitamin B6 requirement |
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Authors: | Katsumi Shibata |
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Institution: | 1. Department of Nutrition, School of Human Nutrition, The University of Shiga Prefecture, Shiga 522-8533, Japanbkshibata@shc.usp.ac.jp |
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Abstract: | The relationship between l-tryptophan to nicotinamide metabolism and the menstrual cycle of Japanese women was investigated. Nine metabolism intermediates from urine samples collected during the preovulatory and postovulatory phases were measured. Only urine 3-hydroxykynurenine was higher in the postovulatory phase than in the preovulatory phase. This increase in 3-hydroxykynurenine suggests a decreased reaction of 3-hydroxykynurenine?→?3-hydroxyanthranilic acid catalyzed by kynureninase, a vitamin B6 enzyme. |
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Keywords: | menstrual cycle nicotinamide ovulatory phase tryptophan vitamin B6 |
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