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Theobromine enhances absorption of cacao polyphenol in rats |
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| Authors: | Takayuki Yamamoto Haruya Takahashi Koichiro Suzuki Akira Hirano Masanori Kamei Tsuyoshi Goto |
| Institution: | 1. Laboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Japan;2. Research Institute, Morinaga and Company Ltd, Yokohama, Japant-yamamoto-jc@morinaga.co.jp;4. Research Institute, Morinaga and Company Ltd, Yokohama, Japan |
| Abstract: | Several concentrations of theobromine (TB) and (?)-epicatechin (EC) were coadministered to rats, and plasma EC and its metabolites were determined using ultra-high-performance liquid chromatography–tandem mass spectrometry. It has been demonstrated that TB increases the absorption of EC in a dose-dependent manner. Cocoa powder had a similar effect, and the mechanism involved is not thought to depend on tight junctions. |
| Keywords: | cacao polyphenol theobromine absorption rat Caco-2 |