Dietary intake of the citrus flavonoid hesperidin affects stress-resilience and brain kynurenine levels in a subchronic and mild social defeat stress model in mice |
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| Authors: | Mizuho Sato Alato Okuno Kazunori Suzuki Natsuki Ohsawa Eiichi Inoue Yuji Miyaguchi |
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| Institution: | 1. Department of Food and Life Sciences, College of Agriculture, Ibaraki University, Ami, Ibaraki, Japan;2. United Graduate School of Agricultural Science, Department of Biological Production Science, Tokyo University of Agriculture and Technology, Fuchu-city, Tokyo, Japan;3. Department of Health and Nutrition, Tsukuba International University, Tsuchiura-city, Ibaraki, Japan;4. United Graduate School of Agricultural Science, Department of Biological Production Science, Tokyo University of Agriculture and Technology, Fuchu-city, Tokyo, Japan;5. Ibaraki University Cooperation between Agriculture and Medical Science (IUCAM), Ami, Ibaraki, Japan;6. Department of Reginal and Comprehensive Agriculture, College of Agriculture, Ibaraki University, Ami, Ibaraki, Japan |
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| Abstract: | ABSTRACTDepressive disorders are partly caused by chronic inflammation through the kynurenine (KYN) pathway. Preventive intervention using anti-inflammatory reagents may be beneficial for alleviating the risk of depression. In this study, we focused on the Japanese local citrus plant, Citrus tumida hort. ex Tanaka (C. tumida; CT), which contains flavonoids such as hesperidin that have anti-inflammatory actions. The dietary intake of 5% immature peels of CT fruits slightly increased stress resilience in a subchronic and mild social defeat (sCSDS) model in mice. Moreover, the dietary intake of 0.1% hesperidin significantly increased stress resilience and suppressed KYN levels in the hippocampus and prefrontal cortex in these mice. In addition, KYN levels in the hippocampus and prefrontal cortex were significantly correlated with the susceptibility to stress. In conclusion, these results suggest that dietary hesperidin increases stress resilience by suppressing the augmentation of KYN signaling under sCSDS. |
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| Keywords: | Depression hesperidin social defeat kynurenine mouse |
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