<Emphasis Type="Italic">In Vitro</Emphasis> and <Emphasis Type="Italic">In Vivo</Emphasis> Evaluation of Hydroxyzine Hydrochloride Microsponges for Topical Delivery |
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Authors: | Christianne Mounir Zaki Rizkalla Randa latif Aziz Iman Ibrahim Soliman |
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Institution: | (1) Faculty of Pharmacy, Cairo University, Kasr Einy, Egypt;(2) Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia |
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Abstract: | Hydroxyzine HCl is used in oral formulations for the treatment of urticaria and atopic dermatitis. Dizziness, blurred vision,
and anticholinergic responses, represent the most common side effects. It has been shown that controlled release of the drug
from a delivery system to the skin could reduce the side effects while reducing percutaneous absorption. Therefore, the aim
of the present study was to produce an effective drug-loaded dosage form that is able to control the release of hydroxyzine
hydrochloride into the skin. The Microsponge Delivery System is a unique technology for the controlled release of topical
agents, and it consists of porous polymeric microspheres, typically 10–50 μm in diameter, loaded with active agents. Eudragit
RS-100 microsponges of the drug were prepared by the oil in an oil emulsion solvent diffusion method using acetone as dispersing
solvent and liquid paraffin as the continuous medium. Magnesium stearate was added to the dispersed phase to prevent flocculation
of Eudragit RS-100 microsponges. Pore inducers such as sucrose and pregelatinized starch were used to enhance the rate of
drug release. Microsponges of nearly 98% encapsulation efficiency and 60–70% porosity were produced. The pharmacodynamic effect
of the chosen preparation was tested on the shaved back of histamine-sensitized rabbits. Histopathological studies were driven
for the detection of the healing of inflamed tissues. |
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