IL-15-induced IL-10 increases the cytolytic activity of human natural killer cells |
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Authors: | Ju Yeong Park Suk Hyung Lee Suk-Ran Yoon Young-Jun Park Haiyoung Jung Tae-Don Kim Inpyo Choi |
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Institution: | (1) Department of Microbiology, University of Otago, PO Box 56, Dunedin, New Zealand |
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Abstract: | Interleukin 10 (IL-10) is a multifunctional cytokine that regulates diverse functions of immune cells. Natural killer (NK)
cells express the IL-10 and IL-10 receptor, but little is known about the function of IL-10 on NK cell activation. In this
study, we show the expression and role of IL-10 in human NK cells. Among the cytokines tested, IL-15 was the most potent inducer
of IL-10, with a maximal peak expression at 5 h after treatment. Furthermore, IL-10 receptor was shown to be expressed in
NK cells. IL-10 alone had a significant effect on NK cytotoxicity which additively increased NK cell cytotoxicity in the presence
of IL-15. Neutralizing IL-10 with anti-IL-10 antibody suppressed the inductive effect of IL-10 on NK cell cytotoxicity; however,
IL-10 had no effect on IFN-γ or TNF-α production or NK cell activatory receptor expression. STAT signals are implicated as
a key mediator of IL-10/IL-15 cytotoxicity response. Thus, the effect of IL-10 on NK cells is particularly interesting with
regard to the STAT3 signal that was enhanced by IL-10 or IL-15. |
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Keywords: | cytotoxicity IL-10 IL-15 natural killer cell |
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