Metabolic profiling reveals the protective effect of diammonium glycyrrhizinate on acute hepatic injury induced by carbon tetrachloride |
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| Authors: | Xiaoyan Wang Jingchao Lin Tianlu Chen Mingmei Zhou Mingming Su Wei Jia |
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| Institution: | (1) Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China;(2) Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China;(3) David H. Murdock Research Institute, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081, USA;(4) Department of Nutrition, University of North Carolina at Greensboro, North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA; |
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| Abstract: | Diammonium glycyrrhizinate (DG), a constitutent of Glycyrrhiza uralensis, has a protective effect on hepatic injury, hepatisis
and cirrhosis. To date, the mechanism has been poorly understood, especially at the metabolic level. A metabolomic profiling
study was performed to characterize the carbon tetrachloride (CCl4) induced global metabolic alteration and the protective effects of DG in Sprague-Dawley rats. Urinary and hepatic tissue
metabolic profiling revealed that CCl4 perturbed the amino acid metabolism (alanine, glycine, leucine), tricarboxylic acid cycle (citrate), lipid metabolism (unsaturated
fatty acids) and gut microbiota related metabolites. Our results also indicated that DG was able to attenuate CCl4 perturbed metabolic pathways and ameliorated biochemical markers of alanine aminotransferase (ALT), aspartate aminotransferase
(AST), and Total cholesterol (TCHO). This global metabolomic approach also revealed full metabolic recovery takes longer than
apparent and conventional histological and biochemical markers. |
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