Synergistic effects in theα
1- andβ
1-adrenergic regulations of intracellular calcium levels in striatal astrocytes |
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Authors: | J C Delumeau P Marin J Cordier J Glowinski J Premont |
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Institution: | Laboratoire de Neuropharmacologie, INSERM U.114, Collège de France, Paris. |
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Abstract: | 1. Using indo-1 as a calcium fluorescent probe, we have observed the following in striatal astrocytes in primary culture. 2. The stimulation of alpha-adrenoceptors induces a rapid rise in cytosolic calcium resulting from an internal calcium mobilization followed by an external calcium influx (4-min duration). 3. The stimulation of beta 1-adrenoceptors evokes only a slight internal calcium mobilization (90-sec duration). 4. The simultaneous stimulation of beta 1- and alpha 1-adrenoceptors induces a more prolonged calcium influx (10 min). The latter phenomenon could explain the calcium-dependent synergistic effects of alpha 1 and beta stimulation on cAMP production already described in the brain. |
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