首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Acute neuronal injury,excitotoxicity, and the endocannabinoid system
Authors:van der Stelt Mario  Veldhuis Wouter B  Maccarrone Mauro  Bär Peter R  Nicolay Klaas  Veldink Gerrit A  Di Marzo Vincenzo  Vliegenthart Johannes F G
Institution:(1) Department of Bio-Organic Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, NL-3584 CH Utrecht, The Netherlands;(2) Department of Experimental in vivo NMR, Image Sciences Institute, Utrecht, University Medical Center Utrecht, The Netherlands;(3) Department of Experimental Neurology, University Medical Center Utrecht, Utrecht, The Netherlands;(4) Department of Experimental Medicine and Biochemical Sciences, University of Rome “Tor Vergata”, Rome, Italy;(5) Endocannabinoid Research Group, Institute of Biomolecular Chemistry—Consiglio Nazionale delle Ricerche, Pozzuoli (Naples), Italy
Abstract:The endocannabinoid system is a valuable target for drug discovery, because it is involved in the regulation of many cellular and physiological functions. The endocannabinoid system constitutes the endogenous lipids anandamide, 2-arachidonoylglycerol and noladin ether, and the cannabinoid CB1 and CB2 receptors as well as the proteins for their inactivation. It is thought that (endo)cannabinoid-based drugs may potentially be useful to reduce the effects of neurodegeneration. This paper reviews recent developments in the endocannabinoid system and its involvement in neuroprotection. Exogenous (endo)cannabinoids have been shown to exert neuroprotection in a variety of in vitro and in vivo models of neuronal injury via different mechanisms, such as prevention of excitotoxicity by CB1-mediated inhibition of glutamatergic transmission, reduction of calcium influx, and subsequent inhibition of deleterious cascades, TNF-α formation, and anti-oxidant activity. It has been suggested that the release of endogenous endocannabinoids during neuronal injury might be a protective response. However, several observations indicate that the role of the endocannabinoid system as a general endogenous protection system is questionable. The data are critically reviewed and possible explanations are given.
Keywords:Cannabinoid  anandamide  2-arachidonoylglycerol  excitotoxicity  neuroprotection  neurodegeneration
本文献已被 PubMed SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号