Biochemical characterization of cuticle polypeptides from the infective larvae of Haemonchus contortus |
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| Authors: | H R Gamble J P Purcell R H Fetterer |
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| Institution: | Helminthic Diseases Laboratory, United States Department of Agriculture, Beltsville, MD 20705. |
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| Abstract: | 1. Ecdysis of infective Haemonchus contortus larvae is effected by the enzymatic degradation of a specialized region of the second molt cuticle containing a biochemically unique polypeptide (mol. wt = 160,000). 2. The 160,000 mol. wt polypeptide and related polypeptides are synthesized at approximately 6 days of larval development. Antigenically similar polypeptides occur in other ruminant trichostrongyles. 3. Cuticle polypeptides digested during ecdysis differ from second molt cuticle collagens in amino acid composition and collagenase sensitivity. However, some antigenic homology between the 160,000 mol. wt polypeptide and cuticle collagens suggests structurally similar regions. |
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