Non enzymic formation of nerolidol from farnesyl pyrophosphate in the presence of bivalent cations |
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| Authors: | C George-Nascimento R Pont-Lezica O Cori |
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| Affiliation: | 1. School of Life Sciences, Institute of Life Sciences and Green Development, Engineering Laboratory of Microbial Breeding and Preservation of Hebei Province, Hebei University, Baoding 071002, China;2. Key Laboratory of Microbial Diversity Research and Application of Hebei Province, Hebei University, Baoding 071002, China;1. School of Life Sciences, Institute of Life Sciences and Green Development, Engineering Laboratory of Microbial Breeding and Preservation of Hebei Province, Hebei University, Baoding 071002, China;2. Key Laboratory of Microbial Diversity Research and Application of Hebei Province, Hebei University, Baoding 071002, China |
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| Abstract: | 1-3H Farnesyl pyrophosphate is hydrolyzed non enzymically at neutral or alkaline pH in the presence of Mg2+ or Mn2+. The pattern of product formation differs for these two ions. In the presence of Mn2+, nerolidol is practically the only reaction product, whereas in the presence of Mg2+ the hydrolysis products are nerolidol and farnesols. The effect of Mg2+ is pH dependent. The formation of nerolidol from mevalonic acid or other precursors of isoprenoids may thus be explained as a non enzymic reaction of farnesyl pyrophosphate. |
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