Regulation of pathways of glucose metabolism in kidney: Specific linking of pentose phosphate pathway activity with kidney growth in experimental diabetes and unilateral nephrectomy |
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Authors: | Keith A. Steer Milena Sochor Ana-Maria Gonzalez McLean Patricia |
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Affiliation: | Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London, W1P 7PN, England |
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Abstract: | The pentose phosphate pathway operates at an elevated level in rat kidney following induction of diabetes and in the compensatory hypertrophy following unilateral nephrectomy in control and alloxan-diabetic rats, as shown by the yields of 14Co2 from [1-14C]glucose, [6-14C]glucose and 3H2O yields from [2-3H]glucose. The elevated flux through the pentose phosphate pathway is correlated with the increased RNA content and weight of the kidney. The direct utilization of NADPH for reductive synthetic reactions and the potential for indirect utilization via the sorbitol route and the linked transhydrogenase reactions of the glucuronate-xylulose pathway, for NADH and ATP generation, are also discussed. |
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Keywords: | [14C]Glucose utilization Pentose phosphate pathway Unilateral nephrectomy Correlation with growth Rat kidney Experimental diabetes |
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