Splenic accumulation of interleukin-3-dependent hematopoietic cells in Friend erythroleukemia. |
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| Authors: | C Spiro B C Gliniak and D Kabat |
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| Institution: | Department of Biochemistry, School of Medicine, Oregon Health Sciences University, Portland 97201-3098. |
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| Abstract: | Interleukin-3-dependent hematopoietic stem cells commonly accumulate in spleens of mice infected with leukemia viruses. To study their origins, a molecularly tagged helper-free Friend spleen focus-forming virus was used to produce erythroleukemias. Uninfected interleukin-3-dependent basophil-mast cell progenitors coproliferated amidst the spleen focus-forming virus-infected leukemic cells. Splenic proliferation of normal stem cells is apparently a host response to leukemogenesis, and we propose that it may contribute to certain retroviral diseases. |
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