Numbers and avidity of anti-DNP antibody plaques in different inbred mouse strains |
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| Authors: | Uswege M. Minga Mariangela Segre Diego Segre |
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| Affiliation: | (1) College of Veterinary Medicine, University of Illinois, 61801 Urbana, Illinois;(2) Present address: East African Veterinary Research Organization, P.O. Kabete, Maguga, Kenya |
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| Abstract: | Spleen cells of mice from eight inbred strains and three F1 hybrids, undergoing a secondary immune response to dinitrophenylated keyhole limpet hemocyanin (DNP-KLH), were examined for numbers of indirect DNP-specific plaque forming cells (PFC) as well as avidity of anti-DNP antibodies. The results indicated that the magnitude of the immune response is under genetic control. Differences in average avidity and heterogeneity of avidity were found among different mouse strains, suggesting genetic control of these parameters. However, no simple pattern of inheritance for these characteristics emerged from the study. |
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