Costs and benefits of resistance against antimalarial drugs |
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Authors: | Koella J C |
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Institution: | Department of Zoology, University of Aarhus, Universitetsparken B135, DK-8000 Aarhus, Denmark. |
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Abstract: | Recent experiments have suggested that resistance to antimalarial drugs, in particular chloroquine, is associated with increased transmission. However, epidemiological patterns suggest the opposite: ie. that resistance should be associated with a transmission cost. Here, Jacob Koella reviews the evidence for either a cost or a benefit of chloroquine resistance and proposes ideas from population and evolutionary biology that might explain the apparent contradiction between experimental and epidemiological evidence. |
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