Fungal metabolites: structural diversity as incentive for anticancer drug development |
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| Authors: | Hendrik Greve Ietidal E Mohamed Alexander Pontius Stefan Kehraus Harald Gross Gabriele M König |
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| Institution: | (1) Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany;(2) Department of Botany, University of Khartoum, Khartoum, Sudan; |
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| Abstract: | Natural products play an important role in the development of anticancer drugs. To date, predominantly metabolites from plants
and bacteria served as lead structures for anticancer agents. Fungal metabolites and derivatives thereof are much less investigated
for their potential in cancer therapy. There are, however, some promising candidates derived from fungi in clinical phases
I and II studies. This review gives an overview on the role of natural products in cancer therapy and summarises some of the
latest results of our group in this area. |
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