| 阶段特异表达的胚胎抗原 |
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| 引用本文： | 滕少辉,赵小立,陆永良,朱旭芬.阶段特异表达的胚胎抗原[J].生命科学,2005,17(3):261-266. |
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| 作者姓名： | 滕少辉 赵小立 陆永良 朱旭芬 |
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| 作者单位： | 1. 浙江大学生命科学学院,杭州,310012
2. 浙江省湖州中心医院,湖州,313000 |
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| 基金项目： | 浙江省重大课题:人胚胎干细胞培养及分化控制(200020579) |
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| 摘 要： | 本文介绍了阶段特异性胚胎抗原(stage specific embryonic antigen，SSEA)的发现、化学结构和在胚胎、成熟组织中的分布规律；SSEA通过参与细胞间的信息传递、细胞识别与粘附等过程在动物胚胎发育、组织分化、基因调控及肿瘤的发生、转移等方面发挥重要作用；SSEA作为细胞表面标志，在肿瘤患者确诊、预后监测及胚胎干细胞的分离纯化、鉴定等研究领域的重要应用价值；探讨了SSEA-1合成的关键酶——岩藻糖基转移酶基因表达与调控的研究进展。
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| 关 键 词： | 胚胎 CD15 岩藻糖基转移酶 |
| 文章编号： | 1004-0374(2005)03-0261-06 |
| 修稿时间： | 2004年9月23日 |
Stage specific embryonic antigen, SSEA |
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| TENG Shao-Hui,ZHAO Xiao-Li,LU Yong-liang,ZHU Xu-Fen.Stage specific embryonic antigen, SSEA[J].Chinese Bulletin of Life Sciences,2005,17(3):261-266. |
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| Authors: | TENG Shao-Hui ZHAO Xiao-Li LU Yong-liang ZHU Xu-Fen |
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| Institution: | TENG Shao-Hui 1,ZHAO Xiao-Li 1,LU Yong-Liang 2,ZHU Xu-Fen 1 * |
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| Abstract: | Stage specific embryonic antigen (SSEA) is an oligosaccharide chain and appears in the forms of glycoprotein and glycolipid, particularly in the glycosylsphingolipid. SSEA expresses wildly in embryonic and adult tissue of mammalian, plays an important role in the embryonic development and differentiation. In the past few years, studies of SSEA have gotten much advance in gene regulation, cell signal transduction, cell recognition, interaction, adhesion and tumor genesis, tumor immigration diagnosis of cancer. This paper intro- duced the discovery, distribution and the latest progresses in the biological function of SSEA. |
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| Keywords: | embryo CD15 fucosyltransferase |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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