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Spontaneous heart disease in the adult chimpanzee (Pan troglodytes) |
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| Authors: | Seiler Brittany M Dick Edward J Guardado-Mendoza Rodolfo VandeBerg John L Williams Jeff T Mubiru James N Hubbard Gene B |
| Affiliation: | College of Veterinary Medicine, Iowa State University, Ames, IA, USA; Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX, USA; Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA |
| Abstract: | Background A high incidence of heart disease, especially idiopathic cardiomyopathy (IC), is seen in chimpanzees ( Pan troglodytes ). Methods We reviewed clinical records and necropsy reports of 87 adult chimpanzees for possible causes of heart disease/IC. We examined age, sex, cause of death, weight, diet, environment, infectious diseases, experimental uses and clinical pathology. Results The overall prevalence of heart disease in chimpanzees was 67.81%; the prevalence of IC was 51.72%. The prevalence of IC was significantly higher in males (60.32%) than that in females (29.17%, P = 0.009). The prevalence of other heart disease was higher in females (25%) than that in males (12.70%, P = 0.165). Heart failure occurred in 47.13% of chimpanzees. Heart disease was the primary cause of death in 34.49% of chimpanzees; 29.88% died of unknown causes. Conclusions We found no evidence that diet, environment, viral agents, experimental use or disease exposure contributed to the deaths resulting from IC in chimpanzees. |
| Keywords: | Ape arteriosclerosis atherosclerosis cardiomyopathy non-human primate |
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