Novel metabolic biomarkers related to sulfur-dependent detoxification pathways in autistic patients of Saudi Arabia |
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| Authors: | Yusra A Al-Yafee Laila Y Al- Ayadhi Samina H Haq Afaf K El-Ansary |
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| Affiliation: | (1) Biochemistry Department, Science College, King Saud University, P.O box 22452, Zip code11495 Riyadh, Saudi Arabia;(2) Autism Research and Treatment Center, Riyadh, Saudi Arabia;(3) Shaik AL-Amodi Autism Research Chair, King Saud University, Riyadh, Saudi Arabia;(4) Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia |
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| Abstract: | Background Xenobiotics are neurotoxins that dramatically alter the health of the child. In addition, an inefficient detoxification system leads to oxidative stress, gut dysbiosis, and immune dysfunction. The consensus among physicians who treat autism with a biomedical approach is that those on the spectrum are burdened with oxidative stress and immune problems. In a trial to understand the role of detoxification in the etiology of autism, selected parameters related to sulfur-dependent detoxification mechanisms in plasma of autistic children from Saudi Arabia will be investigated compared to control subjects. |
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