Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position |
| |
| Authors: | Sun X Moriarty P M Maquat L E |
| |
| Institution: | Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. |
| |
| Abstract: | mRNA for glutathione peroxidase 1 (GPx1) is subject to cytoplasmic nonsense-mediated decay (NMD) when the UGA selenocysteine (Sec) codon is recognized as nonsense. Here, we demonstrate by moving the sole intron of the GPx1 gene that either the Sec codon or a TAA codon in its place elicits NMD when located >/=59 bp but not
|
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
