Babesia canis and Babesia gibsoni: soluble and corpuscular antigens isolated from blood of dogs |
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| Authors: | M Ristic J D Lykins A R Smith D L Huxsall M G Groves |
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| Affiliation: | 1. Biology and Environmental Studies Program, Sciences Cluster, University of the Philippines Cebu, Lahug, Cebu City, Philippines;2. Gullas College of Medicine, University of the Visayas, Banilad, Cebu City 6000, Philippines;3. College of Veterinary Medicine, Cebu Technological University, Barili, Cebu, Philippines;4. National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan;1. Department of Industrial and Information Management, National Cheng Kung University, Tainan, Taiwan;2. College of Economic and Social Development, Nankai University, Tianjin, People''s Republic of China;3. Graduate School of Business and Management, Vanung University, Zhongli District, Taoyuan, Taiwan;1. Division of Hospital Medicine (AM Jenkins, K Auger), Cincinnati Children''s Hospital Medical Center, Cincinnati, OH;2. Department of Internal Medicine (AM Jenkins), University of Cincinnati Medical Center, Cincinnati, OH;3. Division of General Pediatrics (JG Berry, P Dunbar, B Garrity), Boston Children''s Hospital, Harvard Medical School, Boston, Mass;4. Division of General Academic Pediatrics, Department of Pediatrics (JM Perrin, K Kuhlthau), MassGeneral Hospital for Children, Harvard Medical School, Boston, Mass;5. Children''s Hospital Association (M Hall), Lenexa, KS;6. Family Voices (C Hoover), Albuquerque, NM;7. Building Bright Futures (M Crossman), Williston, VT;8. Department of Pediatrics, University of Cincinnati College of Medicine (K Auger), Cincinnati, OH;9. James M. Anderson Center for Health Systems Excellence (K Auger), Cincinnati Children''s Hospital Medical Center, Cincinnati, OH |
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| Abstract: | Babesia canis and Babesia gibsoni were found to be serologically related on the basis of cross-reactions between corpuscular and soluble antigens derived from these organisms and sera of dogs recovered from acute infections caused by each of the parasites. By means of a gel-precipitation (GP) test each Babesia organism possessed at least one species-specific antigen. This antigenic difference was also indicated by the indirect hemagglutination (IHA) test. In the capillary-tube agglutination (CA) and indirect fluorescent antibody (IFA) tests, which used corpuscular antigens of these organisms and undiluted sera, serologic differences between the two organisms was not detected.The time of appearance of antibody detectable in the IHA test was closely correlated with the onset of the disease and appearance of the parasites in the peripheral blood. Based upon results obtained with sera of artificially and naturally infected dogs, the IHA test appears useful for detection and titration of antibodies in canine babesial infections. |
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