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Effects of Plasmodium gallinaceum on hemolymph physiology of Aedes aegypti during parasite development |
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| Authors: | Araujo Ricardo Vieira Maciel Ceres Hartfelder Klaus Capurro Margareth Lara |
| Affiliation: | a Departamento de Clínica Médica, Faculdade de Medicina de São Paulo, Universidade de São Paulo, SP, Brazil b Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, SP, Brazil c Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, SP, Brazil d Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (INCT-EM), Brazil |
| Abstract: | Insect disease vectors show diminished fecundity when infected with Plasmodium. This phenomenon has already been demonstrated in laboratory models such as Aedes aegypti, Anopheles gambiae and Anopheles stephensi. This study demonstrates several changes in physiological processes of A. aegypti occurring upon infection with Plasmodium gallinaceum, such as reduced ecdysteroid levels in hemolymph as well as altered expression patterns for genes involved in vitellogenesis, lipid transport and immune response. Furthermore, we could show that P. gallinaceum infected A. aegypti presented a reduction in reproductive fitness, accompanied by an activated innate immune response and increase in lipophorin expression, with the latter possibly representing a nutritional resource for Plasmodium sporozoites. |
| Keywords: | Vitellogenesis Hemolymph Innate immune response Aedes aegypti Plasmodium gallinaceum |
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