Lipase-catalyzed diacylation of 1,3-butanediol |
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Authors: | Tamotsu Eguchi Kenichi Mochida |
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Institution: | (1) Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. Ltd., Machida, 194 Tokyo, Japan |
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Abstract: | Summary A kinetic resolution of 1,3-butanediol was accomplished by lipase-catalyzed enantioselective diacylations in organic solvent. Diacylation of 1,3-butanediol was carried out using immobilized lipase SP382 (from Candida sp.) to produce (R) -1,3-diacetoxybutane with 85.8% e.e.. And then, this optically active product was chemically hydrolyzed to diol, and re-acylated with lipase SP382 to (R) -1,3-diacetoxybutane with over 98% e.e.. |
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