Chemical constituents from the fruits of Sonneratia caseolaris and Sonneratia ovata (Sonneratiaceae) |
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Authors: | Shi-Biao Wu Ying Wen Xu-Wen Li Yun Zhao Zheng Zhao Jin-Feng Hu |
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Affiliation: | 1. Department of Natural Products for Chemical Genetic Research, Key Laboratory of Brain Functional Genomics, Ministry of Education & Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China;2. Department of Pharmacology and Toxicology, Key Laboratory of Brain Functional Genomics, Ministry of Education & Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China |
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Abstract: | Nine (1–9) and seven (1–6, 10) compounds were isolated from the fruits of Sonneratia caseolaris and Sonneratia ovata, respectively. Their structures were identified by comparing their MS and NMR data as well as the physical properties with the literature. All the isolated compounds were screened against a rat glioma C-6 cell line using the MTT assay method; only compounds (-)-(R)-nyasol (1), (-)-(R)-4′-O-methylnyasol (2) and maslinic acid (6) were found to show moderate cytotoxic activity. Our findings from these two kinds of fruits can be used as a foundation for further chemotaxonomic studies on Sonneratia species. The nor-lignans (1, 2) and 6H-benzo[b,d]pyran-6-one derivatives (3, 4) were isolated from this genus for the first time, indicating that these two classes of compounds may tentatively be considered as taxonomic markers for Sonneratia genus. |
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Keywords: | Sonneratia caseolaris Sonneratia ovata Sonneratiaceae Chemical constituents Cytotoxic activity Chemotaxonomy |
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