1H, 13C, and 15N assignment of the oxidized and reduced forms of T. brucei glutathione peroxidase-type tryparedoxin peroxidase期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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1H, 13C, and 15N assignment of the oxidized and reduced forms of T. brucei glutathione peroxidase-type tryparedoxin peroxidase

Authors:	Johannes Melchers Luise Krauth-Siegel Claudia Muhle-Goll

Institution:	1. Biochemie-Zentrum der Universit?t Heidelberg, Im Neuenheimer Feld 504, 69120, Heidelberg, Germany 2. European Molecular Biology Laboratory, Meyerhofstr.1, 69117, Heidelberg, Germany 3. Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120, Heidelberg, Germany 4. Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany

Abstract:	The cysteine-homologues of glutathione peroxidases in Trypanosoma brucei catalyze the trypanothione/tryparedoxin-dependent reduction of hydroperoxides. We report the ¹H, ¹³C, and ¹⁵N assignment of the oxidized and reduced form of the enzyme by NMR. Major changes between these two forms were only observed for residues close to the catalytic site.

Keywords:	T brucei Peroxidase Tryparedoxin Resonance assignment
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