Hemicentins: What have we learned from worms? |
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作者姓名: | Vogel BE Muriel JM Dong C Xu X |
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作者单位: | Program in Cell Structure and Development, Medical Biotechnology Center, University of Maryland Biotechnology Institute, 725W. Lombard St., Baltimore, MD 21201, USA |
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基金项目: | Acknowledgements This work was funded by the National Institutes of Health (GM 65184), USA. |
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摘 要: | Hemicentins are conserved extracellular matrix proteins discovered in Caenorhabditis elegans, with orthologs in all vertebrate species including human and mouse. Hemicentins share a single, highly conserved amino-terminal von Willebrand A domain, followed by a long (〉40) stretch of immunoglobulin repeats, multiple tandem epidermal growth factors and a fibulin-like carboxy-terminal module. C. elegans has a single hemicentin gene that has pleiotropic functions in transient cell contacts that are required for cell migration and basement membrane invasion and in stable contacts at hemidesmosome-mediated cell junctions and elastic fiber-like structures. Here, we summarize what is known about the function ofhemicentin in C. elegans and discuss implications for hemicentin function in other species.
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关 键 词: | 蠕虫动物 细胞外 细胞连接 生物学 |
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