Severe malarial anemia associated with increased soluble Fas ligand (sFasL) concentrations in Gabonese children |
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Authors: | Issifou Saadou Mavoungou Elie Borrmann Steffen Bouyou-Akotet Marielle K Matsiegui Pierre-Blaise Kremsner Peter G Ntoumi Francine |
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Affiliation: | Unité de Recherches Médicales, H?pital Albert Schweitzer, Lambaréné, Gabon. |
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Abstract: | To investigate if severe malarial anemia is associated with specific cytokine overproduction, we evaluated serum levels of soluble Fas ligand (sFasL), tumor necrosis factor (TNF-alpha) and interleukin-10 (IL-10) from three groups of young children with Plasmodium falciparum infection (asymptomatic cases, uncomplicated malaria cases and severe malarial anemia cases), in a hyperendemic area of Gabon. In uncomplicated cases, only TNF levels were significantly (p < 0.001) increased in comparison to asymptomatic cases with P. falciparum infection. High levels of sFasL, TNF-alpha and IL-10 were associated with low hemoglobin concentrations, sFasL levels were significantly higher in children with severe malarial anemia (p < 0.001) as compared to both other groups. The parasite density was positively correlated with IL-10, TNF-alpha and sFasL levels. TNF-alpha and sFasL, but not IL-10 or parasitemia, were independent predictors of hemoglobin concentrations. These results suggest that, in malaria, a specific dysregulation of the cytokine balance may lead to complications such as severe anemia. |
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