Stimulation of adenosine 3′,5′-monophosphate formation in mononuclear leukocytes by toad venoms |
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Authors: | Viktor Stolc |
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Institution: | Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261 U.S.A. |
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Abstract: | The content of adenosine 3′,5′-monophosphate in human mononuclear leukocytes was enhanced 3–5-times by venoms obtained from African toad (Bufo africanus), American toad (Bufo americanus), Colorado river toad (Bufo arenarum) and Marine toad (Bufo marinus) at 25 μg/ml for 5 min of incubation at 37°C. The maximum stimulation was observed after 1–5 min of incubation. The half-maximal stimulation was observed at 0.1 μg/ml venom obtained from Colorado river toad (Bufo arenarum). The increased content of adenosine 3′,5′-monophosphate in the mononuclear leukocytes persisted without significant change for at least 30 min of incubation at 37°C. |
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Keywords: | Cyclic AMP Toad venom (Mononuclear leukocyte) |
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